VASCULAR BIOLOGY B-crystallin regulation of angiogenesis by modulation of VEGF
نویسندگان
چکیده
1Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles; 2Arnold and Mabel Beckman Macular Research Center at the Doheny Eye Institute, Los Angeles, CA; 3Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles; and 4National Eye Institute, Department of Health and Human Services (DHHS), National Institutes of Health (NIH), Bethesda, MD
منابع مشابه
alphaB-crystallin regulation of angiogenesis by modulation of VEGF.
alphaB-crystallin is a chaperone belonging to the small heat shock protein family. Herein we show attenuation of intraocular angiogenesis in alphaB-crystallin knockout (alphaB-crystallin(-/-)) mice in 2 models of intraocular disease: oxygen-induced retinopathy and laser-induced choroidal neovascularization. Vascular endothelial growth factor A (VEGF-A) mRNA and hypoxia inducible factor-1alpha p...
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تاریخ انتشار 2010